abstract：:Carcinomatous meningitis (CM) occurs in less than 10% of cancer patients. Although patients frequently present with a focal complaint, multifocal signs are often found following careful neurological examination. The gold standard for diagnosis remains the demonstration of neoplastic cells in the cerebrospinal fluid. D...

journal_title：Journal of neuro-oncology

authors： McClelland S 3rd,Garcia RE,Monaco SE,Goldman JE,Olson TJ,Kim GH,Petrylak DP,Goodman RR

更新日期：2006-01-01 00:00:00

abstract：:The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresec...

journal_title：Journal of neuro-oncology

authors： Perilongo G

更新日期：2005-12-01 00:00:00

abstract：:Cancer metastasis can affect any part of the nervous system. When the peripheral nervous system is involved, the usual targets are cranial nerves, nerve roots and plexi. However, peripheral nerves and muscles can also be affected by compression or infiltration of neoplastic cells. This review focuses in the diagnosis ...

journal_title：Journal of neuro-oncology

authors： Ramchandren S,Dalmau J

更新日期：2005-10-01 00:00:00

abstract：:Nuclear factor (NF)-kappaB is known to control cellular proliferation and apoptosis. In malignant astrocytoma cells, it was reported that NF-kappaB was activated aberrantly and promoted their proliferation. Thus, inhibition of NF-kappaB activity is considered to be a promising therapeutic strategy for malignant astroc...

journal_title：Journal of neuro-oncology

authors： Nagai S,Kurimoto M,Washiyama K,Hirashima Y,Kumanishi T,Endo S

更新日期：2005-09-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumors are rare spindle-cell sarcomas derived from Schwann cells or pluripotent cells of the neural crest. They arise from the spinal roots, peripheral nerves, brachial and lumbosacral plexi, cranial nerves and terminal nerve fibers within soft tissue, intestine, lung and bone. These ...

journal_title：Journal of neuro-oncology

authors： Baek WS,Pytel P,Undevia SD,Rubeiz H

更新日期：2005-09-01 00:00:00

abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

journal_title：Journal of neuro-oncology

authors： Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:To study the inhibitory effects of plasmid-based siRNA targeting human epidermal growth factor receptor (EGFR) on tumor proliferation and invasion of TJ905 glioblastoma cells. METHODS:Two siRNA expression constructs targeting human EGFR extracellular domain (516-536) and catalytic domain (2400-2420) were tr...

journal_title：Journal of neuro-oncology

authors： Kang CS,Pu PY,Li YH,Zhang ZY,Qiu MZ,Huang Q,Wang GX

更新日期：2005-09-01 00:00:00

abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

journal_title：Journal of neuro-oncology

authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

更新日期：2005-09-01 00:00:00

abstract：:Majority of the cerebellopontine angle (CPA) tumors are acoustic neuromas, while bulk of the non-acoustic tumors are formed by meningiomas and epidermoid cysts. Primary paraganglioma is a rare tumor in this location, with only two such cases having been reported in the literature, till date. Recently, a case has been ...

journal_title：Journal of neuro-oncology

authors： Deb P,Sharma MC,Gaikwad S,Gupta A,Mehta VS,Sarkar C

更新日期：2005-08-01 00:00:00

abstract：:Craniopharyngiomas and pituitary adenomas are both tumors of the hypothalamic and pituitary region, respectively that are frequently associated with endocrine defects either because of direct involvement of hormone producing cells (most pituitary tumors) or because of secondary defects due to disturbance of hypothalam...

journal_title：Journal of neuro-oncology

authors： Oikonomou E,Barreto DC,Soares B,De Marco L,Buchfelder M,Adams EF

更新日期：2005-07-01 00:00:00

abstract：:Von Hippel-Lindau Disease, a multisystem familial cancer syndrome, is inherited as an autosomal-dominant trait. Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym. We re...

journal_title：Journal of neuro-oncology

authors： Ertas G,Altundag MB,Ucer AR,Cankal F,Altundag K

更新日期：2005-07-01 00:00:00

abstract：:Cavernous sinus is an uncommon site of metastasis for the head and neck tumors, and especially for the tumors of parotid gland. The case reported here is the second reported case of parotid carcinoma metastatic to the cavernous sinus, proven by histopathology. Also it is the first reported parotid gland acinic cell ca...

journal_title：Journal of neuro-oncology

authors： Yildirim N,Oksüzoğlu B,Vural M,Han O,Zengin N

更新日期：2005-06-01 00:00:00

abstract：OBJECT:Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear. We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin ...

journal_title：Journal of neuro-oncology

authors： Fujisawa H,Misaki K,Takabatake Y,Hasegawa M,Yamashita J

更新日期：2005-06-01 00:00:00

abstract：:Conventional Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the cornerstone in the initial evaluation of brain tumours. The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours. We inclu...

journal_title：Journal of neuro-oncology

authors： Fayed N,Modrego PJ

更新日期：2005-05-01 00:00:00

abstract：:Malignant gliomas are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatment. Recent progress on enhanced studies of ion channels involved in glioma cells shed new light on the investigation of glioma cell growth and proliferation. H...

journal_title：Journal of neuro-oncology

authors： Wang WX,Ji YH

更新日期：2005-05-01 00:00:00

abstract：:In January 2003 a symposium was held to discuss the current state of progress and future challenges for the recently described technique of convection enhanced delivery (CED). The focus of the CED symposium was on the potential use of this novel drug delivery technology to enhance the delivery of chemotherapy to malig...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA

更新日期：2005-05-01 00:00:00

abstract：:Gliomatosis cerebri (GC) is regarded as a rare glial neoplasm of unknown origin, and a detailed analysis of molecular alterations underlying this disease has started only recently. However, because GC characteristically affects large parts of the brain and spinal cord, the distribution of genetic alterations may be hi...

journal_title：Journal of neuro-oncology

authors： Mawrin C,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:A retrospective comparison evaluating survival in two well-matched cohorts of patients with cytologically positive neoplastic meningitis (NM) presenting with or without encephalopathy. METHODS:Two cohorts were studied: 20 with and 20 without of NM-related encephalopathy defined as a confusional syndrome. Co...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Tsao-Wei D,Groshen S

更新日期：2005-04-01 00:00:00

abstract：:Antisense bcl-2 therapy combined with chemotherapy has been proved to be effective in various tumors. However, the role played by antisense bcl-2 therapy alone is not clear. In this study, we compared the apoptosis and the protein profiles of antisense bcl-2 transfected human neuroblastoma SK-N-MC cells to the control...

journal_title：Journal of neuro-oncology

authors： Li Y,Lu Z,Chen F,Guan J,Hu L,Xu Y,Chen J

更新日期：2005-03-01 00:00:00

abstract：:Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare with a poor prognosis. We report one case of a 7-year old girl living over 17 months after the diagnosis of AT/RT in the left frontal lobe. Treatment was partial surgical resection and post-operative radiation therapy. Radiation therapy resulted in comple...

journal_title：Journal of neuro-oncology

authors： Howes TL,Buatti JM,O'Dorisio MS,Kirby PA,Ryken TC

更新日期：2005-03-01 00:00:00

abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Benyahia B,Dalmau J,Connan F,Guillet JG,Delattre JY,Choppin J

更新日期：2005-02-01 00:00:00

abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Continuous oral low-dose chemotherapy with methotrexate (MTX) and cyclophosphamide (CPM) has modest activity in heavily pretreated patients with breast cancer. We explored the efficacy of 100 mg CPM daily and 5 mg MTX twice weekly in relapsed glioblast...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Rieger J,Steinbach JP,Nägele T,Dichgans J,Weller M

更新日期：2005-02-01 00:00:00

abstract：:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

journal_title：Journal of neuro-oncology

authors： Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

journal_title：Journal of neuro-oncology

authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

更新日期：2005-01-01 00:00:00

abstract：:During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in huma...

journal_title：Journal of neuro-oncology

authors： Hirschberg H,Sun CH,Tromberg BJ,Yeh AT,Madsen SJ

更新日期：2004-12-01 00:00:00

abstract：:Infiltrative astrocytic neoplasms are by far the most common malignant brain tumors in adults. Clinically, they are highly problematic due to their widely invasive nature which makes a complete resection almost impossible. Biologic progression of these tumors is inevitable and adjuvant therapies are only moderately ef...

journal_title：Journal of neuro-oncology

authors： Kaur B,Tan C,Brat DJ,Post DE,Van Meir EG

更新日期：2004-11-01 00:00:00

abstract：:Successful management of a heavily pretreated 58-year-old woman with metastatic esthesioneuoblastoma using temozolomide is reported. There is no standard treatment of this tumors with extra- and intracranial manifestations. The response, long term stability and high quality of life using temozolomide for this tumor en...

journal_title：Journal of neuro-oncology

authors： Wick W,Wick A,Küker W,Dichgans J,Weller M

更新日期：2004-10-01 00:00:00

abstract：:'Benign' brain tumors are a heterogeneous group of primary neoplasms representing 40% of primary brain tumors. Amongst neuroepithelial tumors, astrocytic neoplasms predominate, followed by oligodendroglial and mixed glial and glial-neuronal neoplasms. Less common are tumors of the ependyma, choroid plexus and neuroepi...

journal_title：Journal of neuro-oncology

authors： Piepmeier J,Baehring JM

更新日期：2004-08-01 00:00:00

abstract：:Malignancy involving the skull base remains a formidable management challenge. Advances and refinements in diagnostic imaging, instrumentation, microvascular reconstruction, and an improved overall appreciation of the anatomy of the skullbase have extended the boundaries of tumor resectability and in some cases, obvia...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：2004-08-01 00:00:00

abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

journal_title：Journal of neuro-oncology

authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

更新日期：2004-07-01 00:00:00

abstract：:Among diffuse gliomas, oligodendrogliomas may account for 25% of cases. They have a better prognosis and chemosensitivity as compared to astrocytomas. Genetic studies have shown a correlation between oligodendrocyte phenotype and presence of 1p/19q deletions. In addition, these deletions are of prognostic value. The a...

journal_title：Journal of neuro-oncology

authors： Bouvier C,Roll P,Quilichini B,Metellus P,Calisti A,Gilles S,Chinot O,Fina F,Martin PM,Figarella-Branger D

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Radiation necrosis is a well-known complication of radiotherapy for malignant brain tumors. Although surgery was once considered the mainstay of treatment, no recent reports have evaluated the use of intraoperative magnetic resonance imaging (IOMRI) and frameless stereotaxis during surgical resection of radia...

journal_title：Journal of neuro-oncology

authors： McPherson CM,Warnick RE

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF). METHODS:Serial collection of plasma samples and brain ECF dialysates after i.v. bolus administration of MTX (50 mg kg(-1)) for 4 h. Quan...

journal_title：Journal of neuro-oncology

authors： Dukic SF,Kaltenbach ML,Heurtaux T,Hoizey G,Lallemand A,Vistelle R

更新日期：2004-03-01 00:00:00

abstract：:Patients with high grade glioma generally have poor prognoses. Addition of radiosensitizing agents might improve the response to irradiation. The chemotherapeutic agent estramustine sensitizes experimental gliomas to radiation. Gliomas express estramustine binding proteins, and cytotoxic concentrations of estramustine...

journal_title：Journal of neuro-oncology

authors： Landy H,Markoe A,Potter P,Lasalle G,Marini A,Savaraj N,Reis I,Heros D,Wangpaichitr M,Feun L

更新日期：2004-03-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

journal_title：Journal of neuro-oncology

authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

更新日期：2004-02-01 00:00:00

abstract：:The objective of this study was to investigate whether activity and protein expression of ornithine decarboxylase (ODC) the metabolism-rate limiting enzyme of the polyamine biosynthesis, which is involved in the regulation of cellular growth and differentiation, reflects the distinct histopathologic characteristics in...

journal_title：Journal of neuro-oncology

authors： Stenzel W,Röhn G,Miletic H,Radner H,Deckert M,Ernestus RI

更新日期：2004-01-01 00:00:00

abstract：:Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

更新日期：2004-01-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00